An Antibiotics and Secondary Metabolites Analysis Shell
Kai BlinDivision for Microbiology/Biotechnology
Biological Background
Biotechnology
Biotechnology - Definition
[...] any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use.The UN Convention on Biological Diversity
Biotechnology


Biofactories
Gene
Nomenclature
Nature's Storage System

DNA

DNA double helix
Amino Acids
Codon Wheel
Central Dogma of Molecular Biology
Gene Cluster
Metabolism
Toxic Waste

Secondary Metabolism






Why do we need more antibiotics?

Non-Ribosomal Peptide Synthesis




Languages Used


Gene Finding
ORF Finding Example
Cluster Identification
Why Use Amino Acid Sequences?
Creating a Profile

Cluster Identification Logic

Cluster BLAST
NRPS Cluster
NRPS Modules
Support Vector Machines

Creating Structures

The Browser is the New OS
Result Page

antiSMASH Web Frontend
- Flask
- Flask-SQLAlchemy
- MySQL
- JQuery
- SVG
Demo Time!
Thank you
Questions?
pigments.jpg by Dan Brady
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