Biological Background

Biotechnology

Biotechnology - Definition

[...] any technological application that uses biological systems, living organisms, or derivatives thereof, to make or modify products or processes for specific use.

Biotechnology

Biofactories

Gene

Nomenclature

Nature's Storage System

DNA

DNA double helix

Amino Acids

Codon Wheel

Central Dogma of Molecular Biology

Gene Cluster

Metabolism

Toxic Waste

Secondary Metabolism

Why do we need more antibiotics?

Non-Ribosomal Peptide Synthesis

Languages Used

Gene Finding

ORF Finding Example

Cluster Identification

Why Use Amino Acid Sequences?

Creating a Profile

Cluster Identification Logic

Cluster BLAST

NRPS Cluster

NRPS Modules

Support Vector Machines

Creating Structures

The Browser is the New OS

Result Page

antiSMASH Web Frontend

• Flask
• Flask-SQLAlchemy
• MySQL
• JQuery
• SVG

Demo Time!

Thank you

Questions?